First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.
نویسندگان
چکیده
Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.
منابع مشابه
Potential for antimicrobial resistance in Chlamydia pneumoniae.
Antimicrobial resistance has not yet been described in wild type Chlamydia pneumoniae isolates, nor has selective emergence of resistance in the laboratory after exposure to subinhibitory concentrations of antibiotic. However, few clinical isolates have been tested for resistance, especially strains with resistance phenotypes (i.e., those associated with clinical failure or persistence). More w...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 48 4 شماره
صفحات -
تاریخ انتشار 2004